Modulatory effect of lifestyle-related risk factors on the mechanisms of subcellular adaptation to myocardial ischemia

Modulatory effect of lifestyle-related risk factors on the mechanisms of subcellular adaptation to myocardial ischemia

 

Number of project: 2/0054/11

 

Principal Investigator: Tatiana Ravingerová

 

Duration: 1.1.2011 – 31.12.2013

 

Annotation:

 

Lifestyle-related fisk factors (RF) including high blood pressure, hyperglycemia and dyslipidemia have a negative impact on the heart exposed to ischemia: they exacerbate irreversible injury (infarction) and incidence of sudden death due to lethal arrhythmias. On the other hand, some stressful factors such as free radicals and enhanced glucose might play a dual role in the mechanism of ischemia-reperfusion injury (IRI) and besides deleterious effects, induce adaptive processes that stimulate mechanisms of  heart’s own resistance to IRI. Enhanced ischemic tolerance that can be evoked via pleiotropic effects of some hypolipidemics is characteristic for female myocardium and is declining with age in both genders. The project is focused on the study of the effects of aforementioned RF on the cellular self-defence mechanisms in relationship with gender differences and age, and on the possibilities to suppress undesired effects of RF by activation of adaptive processes in the heart increasing its tolerance to IRI.